IDENTIFICATION OF A TYPE-SPECIFIC PROTEIN THAT DIFFERENTIATES SEROLOGICALLY BETWEEN HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II

被引：2

作者：

CARRERAZANDOMENI, M ^{[1
]}

ZANDOMENI, R ^{[1
]}

ESTEBAN, EN ^{[1
]}

FERRER, JF ^{[1
]}

机构：

[1] UNIV PENN,NEW BOLTON CTR,SCH VET MED,382 W ST RD,KENNETT SQ,PA 19348

来源：

JOURNAL OF INFECTIOUS DISEASES | 1993年 / 167卷 / 05期

关键词：

D O I：

10.1093/infdis/167.5.1021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The 24-kDa band formed when sera of humans infected with human T cell lymphotropic virus type I (HTLV-1) were reacted with HTLV-I lysates in conventional Western blot (WB) assays was found to be composed of two immunologically unrelated proteins of 24- and 23-kDa. p24, but not p23, carries epitopes shared by the major core proteins of the other known transactivating C-type retroviruses. p23 is unrelated immunologically to the env and tax HTLV-I products but partly cross-reacts with HTLV-I p19. All HTLV-I and simian T cell leukemia virus type I sera tested reacted with p23. Reactivity with p23 was seen with some HTLV-I sera that did not react or reacted weakly with HTLV-I p24. No reactivity with p23 was seen among the 51 human HTLV-II sera tested nor among a large panel of control sera. Because of its type-specificity and strong immunogenicity, p23 provides a reliable serologic marker for the diagnosis of HTLV-I infection and for distinguishing between HTLV-I and -II.

引用

页码：1021 / 1026

页数：6

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