SYNTHESIS OF RUTAECARPINE AND CYTOTOXIC ANALOGS

被引：77

作者：

YANG, LM ^{[1
]}

CHEN, CF ^{[1
]}

LEE, KH ^{[1
]}

机构：

[1] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 05期

关键词：

D O I：

10.1016/0960-894X(95)00046-V

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analogues of rutaecarpine, a quinazolinocarboline alkaloid, were synthesized by structurally modifying the A-ring to yield 10-methoxy (11b), 11-methoxy (11c), and 10,11-methylenedioxy (11d) derivatives. Analogues 11c,d displayed activity superior to rutaecarpine when evaluated against several tumor cell lines in vitro.

引用

页码：465 / 468

页数：4

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