Analysis of Staphylococcus aureus genes encoding penicillin-binding protein 4 and an ABC-type transporter

被引：22

作者：

Domanski, TL ^{[1
]}

Bayles, KW ^{[1
]}

机构：

[1] UNIV MARYLAND,DEPT BIOL SCI,BALTIMORE,MD 21228

来源：

GENE | 1995年 / 167卷 / 1-2期

关键词：

peptidoglycan; cross-linking; transpeptidase; carboxypeptidase;

D O I：

10.1016/0378-1119(96)82965-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A region of the Staphylococcus aureus chromosome has been isolated that contains the gene encoding penicillin-binding protein 4 (PBP4), as well as abcA, a gene that encodes a protein with strong sequence similarity to the ABC transporter family of proteins. A disruption in abcA by Campbell-type integration results in cells that display an increased resistance to methicillin and cefoxitin, two antibiotics known to interact with low-molecular-weight PBPs. Based on these observations, a potential regulatory link between these two genes is discussed.

引用

页码：111 / 113

页数：3

共 13 条

[1] THE USE OF DEGENERATE, SENSOR GENE-SPECIFIC, OLIGODEOXYRIBONUCLEOTIDE PRIMERS TO AMPLIFY DNA FRAGMENTS FROM STAPHYLOCOCCUS-AUREUS [J].