CHARACTERIZATION OF ALPHA(2)-ADRENOCEPTOR SUBTYPES INVOLVED IN THE MODULATION OF GASTRIC-ACID SECRETION

被引：20

作者：

BLANDIZZI, C ^{[1
]}

NATALE, G ^{[1
]}

COLUCCI, R ^{[1
]}

CARIGNANI, D ^{[1
]}

LAZZERI, G ^{[1
]}

DELTACCA, M ^{[1
]}

机构：

[1] UNIV PISA,SCH MED & DENT,INST MED PHARMACOL,I-56126 PISA,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 278卷 / 02期

关键词：

PRESYNAPTIC ALPHA(2)-ADRENOCEPTOR; ALPHA(2)-ADRENOCEPTOR SUBTYPE; GASTRIC ACID SECRETION; VAGUS NERVE; (RAT);

D O I：

10.1016/0014-2999(95)00170-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of several alpha(2)-adrenoceptor agonists and antagonists were examined on gastric acid secretion from reserpinized rats undergoing electrical stimulation of the left vagus nerve. Both detomidine and oxymetazoline inhibited vagal acid hypersecretion, their effects being fully prevented by idazoxan, 7,8-(methylenedioxy)-14-alpha-hydroxyalloberbane (CH 38083), or 2-(2-methoxy-1,4-benzodioxan-2-yl)2-imidazoline (RX 821002), and partly antagonized by yohimbine or rauwolscine. 2-(2,4-(O-methoxy-phenyl)-piperazin-1-yl)-ethyl-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione (ARC 239) did not affect the antisecretory action of the two agonists, while prazosin at the highest dose was partly effective only against detomidine. Atropine markedly reduced vagally evoked acid output. It is suggested that acid secretion induced by vagal cholinergic stimulation is modulated by alpha(2A)-like adrenoceptor subtypes.

引用

页码：179 / 182

页数：4

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