OmicCircos: A Simple-to-Use R Package for the Circular Visualization of Multidimensional Omics Data

被引：145

作者：

Hu, Ying ^{[1
]}

Yan, Chunhua ^{[1
]}

Hsu, Chih-Hao ^{[1
]}

Chen, Qing-Rong ^{[1
]}

Niu, Kelvin ^{[1
]}

Komatsoulis, George A. ^{[1
]}

Meerzaman, Daoud ^{[1
]}

机构：

[1] NCI, Ctr Biomed Informat & Informat Technol, Rockville, MD 20850 USA

来源：

CANCER INFORMATICS | 2014年 / 13卷

关键词：

R package; circular plot; genomic variation;

D O I：

10.4137/CIN.S13495

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

OmicCircos is an R software package used to generate high-quality circular plots for visualizing genomic variations, including mutation patterns, copy number variations (CNVs), expression patterns, and methylation patterns. Such variations can be displayed as scatterplot, line, or text-label figures. Relationships among genomic features in different chromosome positions can be represented in the forms of polygons or curves. Utilizing the statistical and graphic functions in an R/Bioconductor environment, OmicCircos performs statistical analyses and displays results using cluster, boxplot, histogram, and heatmap formats. In addition, OmicCircos offers a number of unique capabilities, including independent track drawing for easy modification and integration, zoom functions, link-polygons, and position-independent heatmaps supporting detailed visualization. AVAILABILITITY AND IMPLEMENTATION: OmicCircos is available through Bioconductor at http://www.bioconductor.org/packages/devel/bioc/html/OmicCircos.html. An extensive vignette in the package describes installation, data formatting, and workflow procedures. The software is open source under the Artistic-2.0 license.

引用

页码：13 / 20

页数：8

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