SPECTROPHOTOMETRIC STUDIES OF SANGUINARINE-B-CYCLODEXTRIN COMPLEX FORMATION

被引：2

作者：

Boldescu, Veaceslav ^{[1
]}

Kacso, Irina ^{[2
]}

Bratu, Ioan ^{[2
]}

Duca, Gheorghe ^{[1
]}

机构：

[1] State Univ Moldova, Dept Ind & Ecol Chem, 60,Mateevici Str, Kishinev MD-2009, Moldova

[2] Nat Inst Res & Dev Isotop & Mol Technol, Cluj Napoca RO-400293, Romania

来源：

CHEMISTRY JOURNAL OF MOLDOVA | 2008年 / 3卷 / 01期

关键词：

sanguinarine; beta-cyclodextrin; inclusion complex; UV-vis spectrophotometry; association constant;

D O I：

10.19261/cjm.2008.03(1).18

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

The main aim of this study was to investigate the infl uence of pH and the presence of hydrophilic polymer polyvinylpyrrolidone on the formation of sanguinarine-beta-cyclodextrin (SANG-beta-CD) inclusion complex. Spectrophotometric studies of the SANG-beta-CD systems in the presence and without 0.1 % PVP at the pH 5.0 did not show any evidence of the complex formation. However, the same systems showed several obvious evidences at the pH 8.0: the hyperchromic and the hypochromic effects and the presence of the isosbestic point in the region of 200-210 nm. The association constants calculated by three linear methods: Benesi-Hildebrand, Scott and Scatchard, were two times higher for the systems with addition of 0.1% PVP than for the systems without it.

引用

页码：85 / 88

页数：4

共 15 条

[1]

Adhami VM, 2004, MOL CANCER THER, V3, P933

[2]

Adhami VM, 2003, CLIN CANCER RES, V9, P3176

[3]

Ahmad N, 2000, CLIN CANCER RES, V6, P1524

[4]

Complex permittivities of cyclomaltooligosaccharides (cyclodextrins) over microwave frequencies to 26 GHz [J].

Atwater, JE .

CARBOHYDRATE RESEARCH, 2000, 327 (03) :219-221

[5]

The alkaloid sanguinarine is effective against multidrug resistance in human cervical cells via bimodal cell death [J].

Ding, ZH ;

Tang, SC ;

Weerasinghe, P ;

Yang, XL ;

Pater, A ;

Liepins, A .

BIOCHEMICAL PHARMACOLOGY, 2002, 63 (08) :1415-1421

[6]

Ling P., 1998, J PHARM SCI, V87, P1535

[7]

Cyclodextrins in topical drug formulations: theory and practice [J].

Loftsson, T ;

Masson, M .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2001, 225 (1-2) :15-30

[8]

Effect of hydroxypropyl-β-cyclodextrin and pH on the solubility of levemopamil HCl [J].

McCandless, R ;

Yalkowsky, SH .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1998, 87 (12) :1639-1642

[9]

Ternary systems of naproxen with hydroxypropyl-β-cyclodextrin and aminoacids [J].

Mura, P ;

Maestrelli, F ;

Cirri, M .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 260 (02) :293-302

[10]

Multicomponent systems of econazole with hydroxyacids and cyclodextrins [J].

Mura, P ;

Faucci, MT ;

Manderioli, A ;

Bramanti, G .

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2001, 39 (1-2) :131-138

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