MECHANISM OF ACTION OF THE 1,2,4-TRIAZOLO[1,5-A] PYRIMIDINES

被引：107

作者：

GERWICK, BC ^{[1
]}

SUBRAMANIAN, MV ^{[1
]}

LONEYGALLANT, VI ^{[1
]}

CHANDLER, DP ^{[1
]}

机构：

[1] DOW CHEM CO USA,CENT RES,MIDLAND,MI 48640

来源：

PESTICIDE SCIENCE | 1990年 / 29卷 / 03期

关键词：

D O I：

10.1002/ps.2780290310

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

The substituted 1,2,4‐triazolo[1,5‐a]pyrimidines are a new class of highly active herbicides. Protection of Arabidopsis thaliana seedlings from triazolopyrimidine‐induced injury by the branched‐chain amino acids was observed. Acetolactate synthase (EC 4.1.3.18) was isolated and found to be quite sensitive to inhibition. I50 values for inhibition of the enzyme from a number of plant sources show little variation and no correlation to whole‐plant response, suggesting uptake, translocation and metabolism play key roles in modulating herbicidal activity. Further studies indicate that these chemicals are slow, tight‐binding inhibitors that are readily dissociated by gel filtration. Some correlations between in‐vitro activity and in‐vivo activity were observed for ortho‐substituted analogs on selected broadleaf species. Copyright © 1990 John Wiley & Sons, Ltd

引用

页码：357 / 364

页数：8

共 13 条

[1]

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[2]

FALCO SC, 1986, BIOTECHNOLOGY PLANT, P313

[3]

LAROSSA RA, 1984, J BIOL CHEM, V259, P8753

[4] 2-CHLORO-N-[(4-METHOXY-6-METHYL-1,3,5-TRIAZIN-2-YL)AMINOCARBONYL]BENZENESULFONAMIDE, A NEW HERBICIDE [J].