RADIATION-INDUCED CROSSLINKING OF PYRIMIDINE OLIGONUCLEOTIDES

被引：7

作者：

DIZDAROGLU, M

SIMIC, MG

机构：

[1] NBS, Radiation Physics Div,, Gaithersburg, MD, USA, NBS, Radiation Physics Div, Gaithersburg, MD, USA

来源：

RADIATION PHYSICS AND CHEMISTRY | 1985年 / 26卷 / 03期

关键词：

CHEMICAL REACTIONS - Crosslinking - CHROMATOGRAPHIC ANALYSIS - MASS SPECTROMETERS - Applications - RADIATION CHEMISTRY - RADIATION EFFECTS;

D O I：

10.1016/0146-5724(85)90070-6

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Small oligonucleotides of thymine and cytosine form crosslinks on gamma irradiation in a N//2O-saturated aqueous solution. Products of crosslinking were separated and isolated by high-performance liquid chromatography and characterized by capillary gas chromatography-mass spectrometry. Quantitative measurements revealed that approximately 50% of primary water radicals account for the crosslinking. Mechanisms of product formation are presented.

引用

收藏

页码：309 / 316

页数：8

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