THYROID-HORMONE INCREASES GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GENE-EXPRESSION IN RAT-LIVER

被引：17

作者：

NESS, GC

PENDLETON, LC

机构：

[1] Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa

来源：

FEBS LETTERS | 1991年 / 288卷 / 1-2期

关键词：

THYROID HORMONE; GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE; NORTHERN BLOTTING CONTROL; RAT LIVER;

D O I：

10.1016/0014-5793(91)80993-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Livers from hypophysectomized rats had low levels of glyceraldehyde 3-phosphate dehydrogenase mRNA. Administration of L-triiodothyronine increased these levels over 20-fold. The peak response was seen 72 h after hormone administration. A half-maximal response was obtained with 5-mu-g of T3 per 100 g of body weight. Thus the expression of hepatic glyceraldehyde 3-phosphate dehydrogenase appears to be regulated by thyroid hormone.

引用

页码：21 / 22

页数：2

共 17 条

[1]

ALEXANDER M, 1985, J BIOL CHEM, V260, P1978

[2] INSULIN STIMULATES GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GENE-EXPRESSION THROUGH CIS-ACTING DNA-SEQUENCES [J].