LOCALIZATION OF THE CYP2D-GENE LOCUS TO HUMAN CHROMOSOME-22Q13.1 BY POLYMERASE CHAIN-REACTION, INSITU HYBRIDIZATION, AND LINKAGE ANALYSIS

被引：53

作者：

GOUGH, AC ^{[1
]}

SMITH, CAD ^{[1
]}

HOWELL, SM ^{[1
]}

WOLF, CR ^{[1
]}

BRYANT, SP ^{[1
]}

SPURR, NK ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND,MOLEC PHARMACOL GRP,EDINBURGH EH8 9XD,SCOTLAND

来源：

GENOMICS | 1993年 / 15卷 / 02期

关键词：

D O I：

10.1006/geno.1993.1082

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Using a combination of somatic cell hybrids, in situ hybridization, and linkage mapping, we have been able to localize the cytochrome P450 CYP2D6 gene to chromosome 22 in the region q13.1. Linkage analysis, using locus-specific primers, showed a maximum sex-average lod score of 8.12 (θ = 0.00) between the marker pH130 (D22S64) and CYP2D6, of 6.92 (θ = 0.00) between the marker KI839 (D22S95) and CYP2D6, and of 4.80 (θ = 0.036) between the platelet-derived growth factor β subunit gene (PDGFB) and CYP2D6. © 1993 by Academic Press, Inc.

引用

页码：430 / 432

页数：3

共 16 条

[1] A CELLULAR ONCOGENE IS TRANSLOCATED TO THE PHILADELPHIA-CHROMOSOME IN CHRONIC MYELOCYTIC-LEUKEMIA [J].

DEKLEIN, A ;

VANKESSEL, AG ;

GROSVELD, G ;

BARTRAM, CR ;

HAGEMEIJER, A ;

BOOTSMA, D ;

SPURR, NK ;

HEISTERKAMP, N ;

GROFFEN, J ;

STEPHENSON, JR .

NATURE, 1982, 300 (5894) :765-767

[2] ISOLATION OF ANONYMOUS, POLYMORPHIC DNA FRAGMENTS FROM HUMAN-CHROMOSOME 22Q12-QTER [J].

DUMANSKI, JP ;

VANKESSEL, AHMG ;

RUTTLEDGE, M ;

WLADIS, A ;

SUGAWA, N ;

COLLINS, VP ;

NORDENSKJOLD, M .

HUMAN GENETICS, 1990, 84 (03) :219-222

[3] INTER-ETHNIC DIFFERENCE IN SPARTEINE OXIDATION AMONG GHANAIANS AND GERMANS [J].

EICHELBAUM, M ;

WOOLHOUSE, NM .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 28 (01) :79-83

[4] CHROMOSOMAL ASSIGNMENT OF HUMAN CYTOCHROME-P-450 (DEBRISOQUINE SPARTEINE TYPE) TO CHROMOSOME 22 [J].

EICHELBAUM, M ;

BAUR, MP ;

DENGLER, HJ ;

OSIKOWSKAEVERS, BO ;

TIEVES, G ;

ZEKORN, C ;

RITTNER, C .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1987, 23 (04) :455-458

[5] DEFECTIVE N-OXIDATION OF SPARTEINE IN MAN - NEW PHARMACOGENETIC DEFECT [J].

EICHELBAUM, M ;

SPANNBRUCKER, N ;

STEINCKE, B ;

DENGLER, HJ .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1979, 16 (03) :183-187

[6] REPORT OF THE COMMITTEE-ON-THE-GENETIC-CONSTITUTION-OF-CHROMOSOME-22 [J].

EMANUEL, BS ;

BUDARF, ML ;

SEIZINGER, BR .

CYTOGENETICS AND CELL GENETICS, 1991, 58 (1-2) :827-852

[7] DEBRISOQUINE 4-HYDROXYLASE - CHARACTERIZATION OF A NEW P450 GENE SUBFAMILY, REGULATION, CHROMOSOMAL MAPPING, AND MOLECULAR ANALYSIS OF THE DA RAT POLYMORPHISM [J].

GONZALEZ, FJ ;

MATSUNAGA, T ;

NAGATA, K ;

MEYER, UA ;

NEBERT, DW ;

PASTEWKA, J ;

KOZAK, CA ;

GILLETTE, J ;

GELBOIN, HV ;

HARDWICK, JP .

DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1987, 6 (02) :149-161

[8] IDENTIFICATION OF THE PRIMARY GENE DEFECT AT THE CYTOCHROME-P450 CYP2D LOCUS [J].

GOUGH, AC ;

MILES, JS ;

SPURR, NK ;

MOSS, JE ;

GAEDIGK, A ;

EICHELBAUM, M ;

WOLF, CR .

NATURE, 1990, 347 (6295) :773-776

[9]

HANIOKA N, 1990, AM J HUM GENET, V47, P994

[10]

JULIER C, 1988, AM J HUM GENET, V42, P297

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