IN-VIVO INDUCTION OF THE GROWTH-ASSOCIATED PROTEIN GAP43/B-50 IN RAT ASTROCYTES FOLLOWING TRANSIENT MIDDLE CEREBRAL-ARTERY OCCLUSION

被引：3

作者：

YAMADA, K ^{[1
]}

GOTO, S ^{[1
]}

OYAMA, T ^{[1
]}

INOUE, N ^{[1
]}

NAGAHIRO, S ^{[1
]}

USHIO, Y ^{[1
]}

机构：

[1] KUMAMOTO UNIV, SCH MED, DEPT NEUROSURG, CEREBROVASC DISORDERS & NEUROSCI LAB, KUMAMOTO 860, JAPAN

来源：

ACTA NEUROPATHOLOGICA | 1994年 / 88卷 / 06期

关键词：

ASTROCYTE; CEREBRUM; GLIAL FIBRILLARY ACIDIC PROTEIN; GROWTH-ASSOCIATED PROTEIN; MIDDLE CEREBRAL ARTERY OCCLUSION;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Immunohistochemistry was used to investigate the induction of growth-associated protein GAP43/B-50 in the astrocytes of rat cerebrum in vivo following ischemic injury produced by 30 min of transient middle cerebral artery occlusion. Three days after operation, GAP43 immunoreactivity first appeared in some astrocytic populations surrounding the infarcted lesion. Induction of GAP43 in those astrocytes persisted for up to 14 days and disappeared at 30 days postoperation. Double-immunofluorescence staining confirmed that the GAP43-immunoreactive astrocytes examined were all positive for glial fibrillary acidic protein. Our present data suggest that certain astrocytes could be induced to synthesize GAP43 in vivo in response to an ischemic insult in adult rats.

引用

页码：553 / 557

页数：5

共 35 条

[1] GLIAL FIBRILLARY ACIDIC PROTEIN IN CRYOGENIC LESIONS OF THE RAT-BRAIN [J].

AMADUCCI, L ;

FORNO, KI ;

ENG, LF .

NEUROSCIENCE LETTERS, 1981, 21 (01) :27-32

[2] A MEMBRANE PHOSPHOPROTEIN ASSOCIATED WITH NEURAL DEVELOPMENT, AXONAL REGENERATION, PHOSPHOLIPID-METABOLISM, AND SYNAPTIC PLASTICITY [J].

BENOWITZ, LI ;

ROUTTENBERG, A .

TRENDS IN NEUROSCIENCES, 1987, 10 (12) :527-532

[3]

BENOWITZ LI, 1991, PROG BRAIN RES, V89, P69

[4]

BLACKWOOD W, 1976, GREENFIELDS NEUROPAT, P24

[5]

BOIS M, 1985, CELL TISSUE RES, V242, P17

[6]

BOVOLENTA P, 1992, PROG BRAIN RES, V94, P367

[7]

CAVANAGH JB, 1970, J ANAT, V106, P471

[8]

CUNHA A, 1990, J CELL BIOL, V111, P209

[9] GROWTH-ASSOCIATED PROTEIN-43 (GAP-43) IS EXPRESSED BY GLIAL-CELLS OF THE CENTRAL AND PERIPHERAL NERVOUS-SYSTEM [J].

CURTIS, R .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1993, 679 :407-411

[10] GAP-43 IS EXPRESSED BY NONMYELIN-FORMING SCHWANN-CELLS OF THE PERIPHERAL NERVOUS-SYSTEM [J].

CURTIS, R ;

STEWART, HJS ;

HALL, SM ;

WILKIN, GP ;

MIRSKY, R ;

JESSEN, KR .

JOURNAL OF CELL BIOLOGY, 1992, 116 (06) :1455-1464

← 1 2 3 4 →