RAT FGF RECEPTOR-4 MESSENGER-RNA IN THE BRAIN IS EXPRESSED PREFERENTIALLY IN THE MEDIAL HABENULAR NUCLEUS

被引：40

作者：

ITOH, N

YAZAKI, N

TAGASHIRA, S

MIYAKE, A

OZAKI, K

MINAMI, M

SATOH, M

OHTA, M

KAWASAKI, T

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT BIOL CHEM,KYOTO,KYOTO 60601,JAPAN

[2] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,KYOTO,KYOTO 60601,JAPAN

[3] UTANO NATL HOSP,CLIN RES CTR,KYOTO,KYOTO 616,JAPAN

来源：

MOLECULAR BRAIN RESEARCH | 1994年 / 21卷 / 3-4期

关键词：

FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR-4; RAT; BRAIN; MEDIAL HABENULAR NUCLEUS; NEURON; MESSENGER-RNA; GENE EXPRESSION;

D O I：

10.1016/0169-328X(94)90265-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The fibrobast growth factor (FGF) receptor family consists of four members, FGFR-1, FGFR-2, FGFR-3 and FGFR-4, that are closely related receptor tyrosine kinases. We examined the expression of rat FGFR-4 mRNA in the brain by in situ hybridization and compared it with that of the mRNAs for other FGF receptors. In contrast with FGFR-1, FGFR-2 and FGFR-3 mRNAs which are expressed widely in the brain, the FGFR-4 mRNA in the brain is expressed preferentially in the medial habenular nucleus neurons. The present finding indicates that FGFR-4 has a function specific to the medial habenular nucleus.

引用

页码：344 / 348

页数：5

共 34 条

[1] KERATINOCYTE GROWTH-FACTOR - A FIBROBLAST GROWTH-FACTOR FAMILY MEMBER WITH UNUSUAL TARGET-CELL SPECIFICITY [J].