ROLE OF 55- AND 75-KDA TNF RECEPTORS IN THE POTENTIATION OF FC-MEDIATED PHAGOCYTOSIS IN HUMAN NEUTROPHILS

被引：9

作者：

DELLABIANCA, V ^{[1
]}

DUSI, S ^{[1
]}

NADALINI, KA ^{[1
]}

DONINI, M ^{[1
]}

ROSSI, F ^{[1
]}

机构：

[1] UNIV VERONA,INST GEN PATHOL,I-37100 VERONA,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 214卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.2254

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human neutrophils respond with an increased phagocytosis when exposed to TNF. Two types of TNF receptors have been identified, namely 55 kDa (TR55) and 75 kDa (TR75). We addressed the problem of the role of these receptors in the priming effect of TNF. By using monoclonal antibodies (MoAbs) directed either against TR55 or TR75, we have shown that 1) only TR55 is the signaling receptor for the potentiation of Fc-mediated phagocytosis and upregulation of beta 2-integrin CD11b/CD18; 2) TR75 may control the function of TR55 by regulating the binding of TNF to the signaling receptor. (C) 1995 Academic Press, Inc.

引用

页码：44 / 50

页数：7

共 24 条

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[2] 75-KDA BUT NOT 55-KDA TUMOR-NECROSIS-FACTOR RECEPTOR IS ACTIVE IN THE HOMOTYPIC AGGREGATION AND PROLIFERATION OF HUMAN LYMPHOKINE-ACTIVATED T-KILLER (T-LAK) CELLS IN-VITRO [J].