THE RELATIONSHIP BETWEEN THE 140S ANTIGEN DOSE IN AQUEOUS FOOT-AND-MOUTH-DISEASE VACCINES AND THE SERUM ANTIBODY-RESPONSE OF CATTLE

被引：40

作者：

RWEYEMAMU, MM ^{[1
]}

BLACK, L ^{[1
]}

BOGE, A ^{[1
]}

THORNE, AC ^{[1
]}

TERRY, GM ^{[1
]}

机构：

[1] IMPSTOFFWERK WELLCOME GMBH, D-3006 BURGWEDEL 1, GERMANY

来源：

JOURNAL OF BIOLOGICAL STANDARDIZATION | 1984年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0092-1157(84)80027-X

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Groups of 8 or 12 cattle were injected with dilutions of aqueous saponized vaccines containing 329,760 to 7 ng of 140S O1BFS 1860 strain foot-and-mouth disease antigen/dose. Four mo. later the animals were subdivided into groups of 4 and revaccinated with vaccines containing 329,760, 9160 and 42 ng of antigen/dose. Responses were established by taking serum samples from the animals periodically and examining these for neutralizing antibody activity. The results showed that after primary vaccinatin the dose of antigen in vaccines influenced the earliest time of protection, the peak antibody titers attained and probably, the duration of immunity. At 21 days after vaccination the log antigen-antibody response slope was linear between 7 and 9, 160 ng, with an inclinatin of 0.53, indicating that every doubling of the vaccine antigen dose produced an increase of 0.16 log10SN50 in the mean serum antibody titer. The secondary response was influenced by the antigen dose in the second vaccination and to a leser extent by that in the first vaccination also.

引用

页码：111 / 120

页数：10

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