IDENTIFICATION OF BLAR, THE SIGNAL TRANSDUCER FOR BETA-LACTAMASE PRODUCTION IN BACILLUS-LICHENIFORMIS, AS A PENICILLIN-BINDING PROTEIN WITH STRONG HOMOLOGY TO THE OXA-2 BETA-LACTAMASE (CLASS-D) OF SALMONELLA-TYPHIMURIUM

被引：44

作者：

ZHU, YF

CURRAN, IHA

JORIS, B

GHUYSEN, JM

LAMPEN, JO

机构：

[1] RUTGERS STATE UNIV, WAKSMAN INST, PISCATAWAY, NJ 08855 USA

[2] UNIV LIEGE, SERV MICROBIOL, B-4000 LIEGE, BELGIUM

来源：

JOURNAL OF BACTERIOLOGY | 1990年 / 172卷 / 02期

关键词：

D O I：

10.1128/jb.172.2.1137-1141.1990

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The blaR gene of Bacillus licheniformis encodes the signal transducer for induction of the class A β-lactamase. The protein produce, BlaR, has a hydrophilic region that binds β-lactams and shows high sequence homology to the class D β-lactamases, particularly the OXA-2 β-lactamase of Salmonella typhimurium. The BlaR-β-lactam complex is stable and may provide the continuing stimulus needed for the prolonged production of the enzyme.

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页码：1137 / 1141

页数：5

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