BRADYKININ ANTAGONIZES MORPHINE-INDUCED ANALGESIA IN RATS

被引：4

作者：

ARGIOLAS, A ^{[1
]}

MELIS, MR ^{[1
]}

GESSA, GL ^{[1
]}

机构：

[1] UNIV CAGLIARI, INST PHARMACOL, VIA PORCELL 4, I-09100 CAGLIARI, ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1985年 / 112卷 / 02期

关键词：

D O I：

10.1016/0014-2999(85)90510-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The intraventricular injection of 5 .mu.g of bradykinin or Met-Lys-bradykinin in rats antagonized the increase in nociception threshold induced by morphine (5 .mu.g i.c.v. [intracerebroventricularly] or 10 mg/kg i.p.) in the tail flick test. The effect of the 2 kinins was prevented by atropine (30 mg/kg i.p.). Bradykinin apparently counteracts opiate activity in the CNS by enhancing acetylcholine release.

引用

页码：277 / 280

页数：4

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