SODIUM-ACETATE IMPROVES THE OCULAR SYSTEMIC ABSORPTION RATIO OF TIMOLOL APPLIED OCULARLY IN MONOISOPROPYL PVM-MA MATRICES

被引：9

作者：

FINNE, U

SALIVIRTA, J

URTTI, A

机构：

[1] Department of Pharmaceutical Technology, SF-70211 Kuopio

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 75卷 / 01期

关键词：

TIMOLOL; SODIUM ACETATE; OCULAR ABSORPTION; SYSTEMIC ABSORPTION; POLY(VINYL METHYL ETHER MALEIC ANHYDRIDE);

D O I：

10.1016/0378-5173(91)90256-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The safety of ocularly applied timolol can be increased by administering the drug in polymer matrices instead of eye drops. This study shows that addition of sodium acetate to the monoisopropyl PVM-MA matrices improves the aqueous humor/plasma concentration ratio of timolol about 20-fold as compared to the matrices buffered with disodium phosphate. Thus, sodium acetate seems to decrease specifically the systemic but not the ocular absorption of timolol.

引用

页码：R1 / R4

页数：4

共 10 条

[1] NASAL AND CONJUNCTIVAL CONTRIBUTIONS TO THE SYSTEMIC ABSORPTION OF TOPICAL TIMOLOL IN THE PIGMENTED RABBIT - IMPLICATIONS IN THE DESIGN OF STRATEGIES TO MAXIMIZE THE RATIO OF OCULAR TO SYSTEMIC ABSORPTION [J].