IMPROVED PROTECTION AND ESTERIFICATION OF A PRECURSOR OF THE TAXOTERE(R) AND TAXOL SIDE-CHAINS

被引：150

作者：

COMMERCON, A

BEZARD, D

BERNARD, F

BOURZAT, JD

机构：

[1] Rhône-Poulenc Rorer - Centre de Recherches de Vitry-Alfortville 13, 94403 Vitry-sur-Seine

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 36期

关键词：

D O I：

10.1016/S0040-4039(00)79128-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(4S,5R)-N-BOC-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylic acid 8 was prepared and efficiently esterified by conveniently protected baccatins 9a,b. Smooth deprotection in formic acid gave the N-deprotected intermediates of Taxotere(R) and taxol. This protocol did not generate any epimerization at C-2' and constitutes a pratical method to prepare Taxotere(R), taxol and analogs.

引用

页码：5185 / 5188

页数：4

共 21 条

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