CD8(+) T-CELL SUBSETS IN AGING

被引：11

作者：

RUIZ, M ^{[1
]}

ESPARZA, B ^{[1
]}

PEREZ, C ^{[1
]}

BARRANQUERO, M ^{[1
]}

SABINO, E ^{[1
]}

MERINO, F ^{[1
]}

机构：

[1] BILBAO CITY COUNCIL MED SERV, E-48940 BILBAO, SPAIN

来源：

IMMUNOLOGICAL INVESTIGATIONS | 1995年 / 24卷 / 06期

关键词：

D O I：

10.3109/08820139509060715

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infections are a major cause of illness and death amongst elderly people. Peripheral blood CD8(+) T lymphocytes -which play a crucial role in host defence against viral infections-. are divided in subsets based upon the expression of several cell and activation markers. Since in senescence changes in peripheral blood CD8(+) T lymphocyte compartment have been described, studies were performed to determine whether in aging there are variations in the peripheral blood CD8(+)CD38(+), CD8(+)CD57(+), CD8(+)HLA-DR(+), CD8(+)CD45RA(+) and CD8(+)CD45RO(+) cell subset. A decrease in the CD8(+)CD45RA(+) lymphocytes was observed, indicating that variations in the CD8(+) compartment can take place with ageing.

引用

页码：891 / 895

页数：5

共 19 条

[1]

CALLAHAN JE, 1993, J IMMUNOL, V151, P6657

[2] AGE-RELATED-CHANGES IN HUMAN-LYMPHOCYTE SUBSETS - PROGRESSIVE REDUCTION OF THE CD4 CD45R (SUPPRESSOR INDUCER) POPULATION [J].