THE EFFECTS OF FLUOXETINE ON THE POLYSOMNOGRAM OF DEPRESSED OUTPATIENTS - A PILOT-STUDY

被引：45

作者：

HENDRICKSE, WA ^{[1
]}

ROFFWARG, HP ^{[1
]}

GRANNEMANN, BD ^{[1
]}

ORSULAK, PJ ^{[1
]}

ARMITAGE, R ^{[1
]}

CAIN, JW ^{[1
]}

BATTAGLIA, J ^{[1
]}

DEBUS, JR ^{[1
]}

RUSH, AJ ^{[1
]}

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT PSYCHIAT,DALLAS,TX 75235

来源：

NEUROPSYCHOPHARMACOLOGY | 1994年 / 10卷 / 02期

关键词：

FLUOXETINE; NORFLUOXETINE; POLYSOMNOGRAPHY; SEROTONIN; DEPRESSION;

D O I：

10.1038/npp.1994.10

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of fluoxetine (FLU) and its active metabolite, norfluoxetine (NFLU), on the polysomnogram (PSG) of nine depressed outpatients (eight with major depression; one with bipolar II, depressed phase disorder) were investigated by contrasting PSG values prior to treatment anti during administration of FLU. The PSG changes were correlated with daily dose, cumulative dosage, single serum concentrations, and the total area under the serum concentration curve (AUC) of both FLU and NFLU. Fluoxetine clearly increased both stage 1 sleep time and rapid-eye-movement (REM) latency and decreased both percent REM and REM density. With a few exceptions, the cumulative dosage of FLU and the AUC of FLU and NFLU were better predictors of the changes in awake and movement time in the PSG than single-sample concentrations of FLU and NFLU taken at the time of PSG assessment.

引用

页码：85 / 91

页数：7

共 29 条

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[2]

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