IMMUNE AGING AND ALZHEIMERS-DISEASE

被引：33

作者：

HARTWIG, M ^{[1
]}

机构：

[1] FREE UNIV BERLIN, KLINIKUM BENJAMIN FRANKLIN, INST NEUROPATHOL, D-12200 BERLIN, GERMANY

来源：

NEUROREPORT | 1995年 / 6卷 / 09期

关键词：

ALZHEIMERS DISEASE; IMMUNE AGING; MICROGLIA; AUTOREACTIVE T CELLS; T CELL APOPTOSIS;

D O I：

10.1097/00001756-199506090-00011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE implications of immune ageing are considered with respect to Alzheimer's disease. In the course of immune ageing a population of activated autoreactive T cells appears which is proposed to cross the undamaged blood-brain barrier and to initiate overactivation of brain microglia. The development of highly activated microglia appears to be sufficient to induce the inflammatory neurotoxic process characteristic of the brain in Alzheimer's disease. The model thus emerging for sporadic Alzheimer's disease is that of a T cell-mediated chronic autoimmune syndrome following the age-dependent loss of thymic function. This view is consistent with available data and provides testable predictions.

引用

页码：1274 / 1276

页数：3

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