AUTOANTIBODIES TO GLUTAMIC-ACID DECARBOXYLASE IN PALATAL MYOCLONUS AND EPILEPSY

被引：83

作者：

NEMNI, R

BRAGHI, S

NATALISORA, MG

LAMPASONA, V

BONIFACIO, E

COMI, G

CANAL, N

机构：

[1] UNIV MILAN,IST SCI SAN RAFFAELE,DEPT NEUROL,MILAN,ITALY

[2] UNIV MILAN,IST SCI SAN RAFFAELE,DEPT INTERNAL MED,MILAN,ITALY

来源：

ANNALS OF NEUROLOGY | 1994年 / 36卷 / 04期

关键词：

D O I：

10.1002/ana.410360419

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report the presence of serum autoantibodies directed against glutamic acid decarboxylase in a patient with epilepsy and palatal myoclonus not associated with brain lesions. Glutamic acid decarboxylase antibody reactivity was dependent on the presence of carboxy-terminal amino acids, similar to that reported in patients with stiff-man syndrome. Marked reduction in the frequency of epileptic attacks and improvement in palatal myoclonus occurred when benzodiazepine was administered and phenytoin was gradually tapered. Testing for antiglutamic acid decarboxylase antibodies may be indicated in patients with palatal myoclonus and with convulsive disorders refractory to therapy.

引用

页码：665 / 667

页数：3

共 19 条

[1] IDENTIFICATION OF THE 64K AUTOANTIGEN IN INSULIN-DEPENDENT DIABETES AS THE GABA-SYNTHESIZING ENZYME GLUTAMIC-ACID DECARBOXYLASE [J].