A HIGH-RESOLUTION INTERVAL MAP OF THE Q21 REGION OF THE HUMAN X-CHROMOSOME

被引：15

作者：

PHILIPPE, C

ARNOULD, C

SLOAN, F

VANBOKHOVEN, H

VANDERVELDEVISSER, SD

CHERY, M

ROPERS, HH

GILGENKRANTZ, S

MONACO, AP

CREMERS, FPM

机构：

[1] CRTS, GENET HUMAINE LAB, F-54511 VANDOEUVRE LES NANCY, FRANCE

[2] UNIV NIJMEGEN HOSP, DEPT HUMAN GENET, 6500 HB NIJMEGEN, NETHERLANDS

来源：

GENOMICS | 1995年 / 27卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/geno.1995.1089

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In a previous study, we have developed a panel of chromosomal rearrangements for the physical mapping of the q13-q21 region of the human X chromosome (Philippe et al., Genomics 17: 147-152, 1993). Here, we report the physical localization of 36 additional polymorphic markers by polymerase chain reaction analysis. The high density of chromosomal breakpoints in Xq21 allows us to map 58 DNA loci in 22 intervals. As a result, this segment of the X chromosome is saturated with approximately three sequence tagged sites' per megabase of DNA, which will facilitate the construction of a YAC contig of this region. (C) 1995 Academic Press, Inc.

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收藏

页码：539 / 543

页数：5

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