3',4'-DIETHYNYL-2',3',5'-TRIDEOXY-5'-NORURIDINE - A NEW SELF-POLYMERIZABLE 2'-DEOXYRIBONUCLEOSIDE ANALOG

被引：4

作者：

AMIN, MA ^{[1
]}

STOECKLIEVANS, H ^{[1
]}

GOSSAUER, A ^{[1
]}

机构：

[1] UNIV FREIBURG,INST ORGAN CHEM,W-1700 FREIBURG,GERMANY

来源：

HELVETICA CHIMICA ACTA | 1995年 / 78卷 / 07期

关键词：

D O I：

10.1002/hlca.19950780721

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In 10 steps, 3',4'-diethynyl-2',3',5'-trideoxy-5'-noruridine (14) was synthesized in 5% overall yield from commercial uridine, using conventional methods of nucleoside chemistry. As two functional groups capable to react with each other are present in the same molecule, the synthetic compound is able to form polymers, similar to the polynucleotides, by acetylene coupling reaction.

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页码：1879 / 1886

页数：8

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