SELECTIVE ENHANCEMENT OF INTRATUMORAL BLOOD-FLOW IN MALIGNANT GLIOMAS USING INTRAARTERIAL ADENOSINE-TRIPHOSPHATE

被引：9

作者：

BABA, T ^{[1
]}

FUKUI, M ^{[1
]}

TAKESHITA, I ^{[1
]}

ICHIYA, Y ^{[1
]}

KUWABARA, Y ^{[1
]}

HASUO, K ^{[1
]}

机构：

[1] KYUSHU UNIV 60,FAC MED,DEPT RADIOL,FUKUOKA 812,JAPAN

来源：

JOURNAL OF NEUROSURGERY | 1990年 / 72卷 / 06期

关键词：

adenosine triphosphate; Drug delivery; glioma; positron emission tomography; regional blood flow;

D O I：

10.3171/jns.1990.72.6.0907

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effect of intravenous and intracarotid administration of adenosine triphosphate (ATP) on the regional blood flow of glioma patients has been examined by means of positron emission tomography. Intracarotid administration of ATP at a dose of 0.52 to 1.3 μg/kg/min selectively increased the blood flow in the tumor by 26.2% ± 10.5% (mean ± standard deviation). The side effects observed were tolerable. In contrast, intravenous administration of ATP failed to increase tumor blood flow. It is suggested that intracarotid administration of ATP may serve to selectively enhance the delivery of anticancer agents to malignant brain tumors.

引用

页码：907 / 911

页数：5

共 19 条

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