DIRECT HPLC SEPARATION AND OPTIMIZATION OF CELIPROLOL ENANTIOMERS

被引：25

作者：

ABOULENEIN, HY

ISLAM, MR

机构：

[1] Drug Development Laboratory, Radionuclide & Cyclotron Operations, King Faisal Specialist Hospital & Research Centre, Riyadh 11211

来源：

ANALYTICAL LETTERS | 1990年 / 23卷 / 01期

关键词：

Celiprolol; Cellulose based chiral stationary phase; Chiral chromatography; Enantiomeric resolution; Enantiomers; HPLC enantiomeric separation; β-Adrenergic blocker;

D O I：

10.1080/00032719008052427

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Celiprolol enantiomers were resolved without any derivatization using a high performance liquid chromatographic system on a cellulose tris-3, 5-dimethylphenyl carbamate column (CHIRALCEL-OD). Maximum stereochemical resolution (R) obtained with symmetrical peaks was 2.94, The effects of 2-propanol and die thylamine content in mobile phas'e and effect of temperature on capacity factor (k), stereochemical separation factor (a) and stereochemical resolution factor (R) are demonstrated. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：83 / 91

页数：9

共 8 条

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