NOVEL GENERATION OF HORMONE RECEPTOR SPECIFICITY BY AMINO TERMINAL PROCESSING OF PEPTIDE-YY

被引:71
作者
GRANDT, D
TEYSSEN, S
SCHIMICZEK, M
REEVE, JR
FETH, F
RASCHER, W
HIRCHE, H
SINGER, MV
LAYER, P
GOEBELL, H
HO, FJ
EYSSELEIN, VE
机构
[1] UNIV ESSEN GESAMTHSCH, DEPT MED STAT, W-4300 ESSEN 1, GERMANY
[2] UNIV HEIDELBERG, KLINIKUM MANNHEIM, DIV GASTROENTEROL, W-6900 HEIDELBERG, GERMANY
[3] VET ADM WADSWORTH MED CTR, LOS ANGELES, CA 90073 USA
[4] UNIV CALIF LOS ANGELES, LOS ANGELES CTY HARBOR MED CTR, CTR INFLAMMATORY BOWEL DIS, TORRANCE, CA 90509 USA
[5] UNIV CALIF LOS ANGELES, CURE, CTR DIGEST DIS, LOS ANGELES, CA 90073 USA
[6] UNIV ESSEN GESAMTHSCH, DEPT PEDIAT, W-4300 ESSEN 1, GERMANY
关键词
D O I
10.1016/S0006-291X(05)81547-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The physiological significance of multiple Y receptors has not been determined since until recently only one form of endogenous agonists was known, namely PYY1-36 and NPY1-36. Recently, a new molecular form of PYY was characterized as des(Tyr-Pro)PYY (PYY3-36 or PYY-II). Its ability to interact at various Y receptors was not characterized. Analytical chromatography of fresh canine colon extracts shows two peaks of immunoreactivity eluting in the positions of PYY-II and PYY1-36 (PYY). PYY-II was about 40% of the total PYY immunoreactivity indicating that it is one of the major forms of PYY expressing its biological activity. It is shown that PYY-II will not displace label from the Yl receptors found on a human neuroblastoma cell line. It is further shown that PYYII is as potent as PYY for the inhibition of pancreatic secretion, which must occur through Y2 receptors. The enzymatic removal of Tyr-Pro from PYY to form PYYII must therefore regulate the relative expression of a non-selective agonist (PYY) to a highly selective Y2 agonist (PYY-II). Amino terminal processing of PYY represents a novel type of regulation of peptide hormone specificity. It has important biological implications for PYY and potential relevance for other peptide hormone receptor systems. © 1992 Academic Press, Inc.
引用
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页码:1299 / 1306
页数:8
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