DIFFERENTIAL-EFFECTS OF TESTOSTERONE METABOLITES UPON THE SIZE OF SEXUALLY DIMORPHIC MOTONEURONS IN ADULTHOOD

被引:42
作者
FORGER, NG [1 ]
FISHMAN, RB [1 ]
BREEDLOVE, SM [1 ]
机构
[1] UNIV CALIF BERKELEY,GRAD GRP NEUROBIOL,BERKELEY,CA 94720
关键词
D O I
10.1016/0018-506X(92)90042-T
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
This study examined the effect of testosterone and two of its metabolites on the size of motoneurons in the sexually dimorphic spinal nucleus of the bulbocavernosus (SNB) in adult male rats. Treatment of castrates with either testosterone or dihydrotestosterone maintained SNB cell size, although testosterone was more effective in this regard. However, estradiol, either alone or in conjunction with dihydrotestosterone treatment, had no effect on the size of the somata or nuclei of SNB motoneurons. These results indicate that testosterone affects SNB cell size by interacting with androgen receptors and that aromatized metabolites of testosterone are not involved in this aspect of motoneuronal plasticity in adulthood. Because the penile reflexes mediated by the SNB neuromuscular system are also sensitive to androgen but not estrogen treatment, morphological changes in SNB cells may contribute to the androgenic modulation of these reflexes. © 1992.
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收藏
页码:204 / 213
页数:10
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