IMPROVED SIB-PAIR LINKAGE TEST FOR DISEASE SUSCEPTIBILITY LOCI

被引：24

作者：

FARAWAY, JJ

机构：

[1] Department of Statistics, University of Michigan, Ann Arbor

来源：

GENETIC EPIDEMIOLOGY | 1993年 / 10卷 / 04期

关键词：

MOST POWERFUL TEST; SIB-PAIR METHOD; CHI-SQUARED GOODNESS OF FIT STATISTIC;

D O I：

10.1002/gepi.1370100403

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

An improved sib-pair test for linkage is introduced which is superior to the previously proposed tests. The test is derived from the standard chi-squared goodness of fit statistic by restricting the alternative hypothesis to the genetically possible. Critical values are given and exact power comparisons are made with the previously proposed tests. The new test is shown to be more powerful for finite samples as well as being asymptotically uniformly most powerful. (C) 1993 Wiley-Liss, Inc.

引用

页码：225 / 233

页数：9

共 22 条

[1]

BLACKWELDER W C, 1985, Genetic Epidemiology, V2, P85, DOI 10.1002/gepi.1370020109

[2]

CONCANNON P, 1990, AM J HUM GENET, V47, P45

[3]

COX NJ, 1988, AM J HUM GENET, V42, P167

[4] EVIDENCE FOR HL-A-LINKED GENES IN JUVENILE DIABETES-MELLITUS [J].

CUDWORTH, AG ;

WOODROW, JC .

BRITISH MEDICAL JOURNAL, 1975, 3 (5976) :133-135

[5]

DAY NE, 1976, TISSUE ANTIGENS, V8, P109

[6]

DEVRIES RRP, 1976, LANCET, V2, P1328

[7] ASSOCIATION AND SIBPAIR ANALYSIS FOR THE HLA, GM, KM, AND INSULIN POLYMORPHISMS IN MULTIPLEX IDDM FAMILIES [J].

FIMMERS, R ;

NEUGEBAUER, M ;

DENNERT, J ;

WIENKER, T ;

BAUR, MP .

GENETIC EPIDEMIOLOGY, 1989, 6 (01) :107-112

[8]

FISHMAN PM, 1978, AM J HUM GENET, V30, P308

[9]

Fletcher R., 1981, PRACTICAL METHODS OP

[10] FAMILIAL TESTICULAR CANCER - A REPORT OF THE UK FAMILY REGISTER, ESTIMATION OF RISK AND AN HLA CLASS-1 SIB-PAIR ANALYSIS [J].

FORMAN, D ;

OLIVER, RTD ;

BRETT, AR ;

MARSH, SGE ;

MOSES, JH ;

BODMER, JG ;

CHILVERS, CED ;

PIKE, MC .

BRITISH JOURNAL OF CANCER, 1992, 65 (02) :255-262

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