BIOLOGICAL AND BIOCHEMICAL-PROPERTIES OF THE SMALL VIRAL RNA(PRNA) ESSENTIAL FOR THE PACKAGING OF THE DSDNA OF PHAGE PHI-29

被引：37

作者：

GUO, PX ^{[1
]}

TROTTIER, M ^{[1
]}

机构：

[1] PURDUE UNIV,PURDUE BIOCHEM & MOLEC BIOL PROGRAM,W LAFAYETTE,IN 47907

来源：

SEMINARS IN VIROLOGY | 1994年 / 5卷 / 01期

关键词：

BACTERIOPHAGE-PHI-29; VIRAL DNA PACKAGING; ATPASE; SMALL RNA; PRNA; RNA STRUCTURE AND FUNCTION;

D O I：

10.1006/smvy.1994.1004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The genome of the lineal double-stranded DNA viruses of both prokaryotes and eukaryotes is packaged into a preformed procapsid during maturation. Common features exist in this step of the viral life cycle. Bacteriophage ø29 is an ideal model in this study because its DNA can be efficiently packaged in vitro with all components overproduced and purified. An exciting aspect is the discovery that a small viral RNA (pRNA) encoded by ø29 has a novel and essential role in viral DNA packaging. This pRNA is not a structural component of the mature virion, nor is it required for the assembly of the procapsid. The discovery of pRNA as a non-protein participant in viral DNA packaging extends previously demonstrated RNA functions. © 1994 Academic Press. All rights reserved.

引用

页码：27 / 37

页数：11

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