OOCYTE DONATION - THE ROLE OF ENDOMETRIAL RECEPTIVITY

被引：28

作者：

DAVIES, MC

ANDERSON, MC

MASON, BA

JACOBS, HS

机构：

[1] Department of Reproductive Endocrinology, Cobbold Laboratories, University College and Middlesex School of Medicine, London W1, Mortimer Street

[2] Department of Histopathology, St Mary's Hospital Medical School, London W2, Praed Street

[3] Hallam Medical Centre, London W1

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 07期

关键词：

Donor gametes; Endometrium; Implantation;

D O I：

10.1093/oxfordjournals.humrep.a137199

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Sixteen patients, 15 with primary ovarian failure and one carrier of chromosomal abnormality, received 21 embryo transfers following in-vitro fertilization of donated oocytes. Hormone replacement therapy was given to mimic a natural menstrual cycle. Five pregnancies were achieved (four infants delivered and one early pregnancy loss). All patients had endometrial biopsies taken in a preceding cycle of hormone replacement therapy. The majority (61%) showed delayed maturation compared with the expected appearances for the day of the cycle as assessed on light microscopy. Patients who conceived had a significantly better endometrial respome than those who did not. Five out of seven patients (71%) conceived when the endometrium was 'in phase' (<2 days' delay). This suggests that endometrial receptivity is a key factor in conception. The implications for improving outcome from in-vitro fertilization treatment are discussed. © 1990 Oxford University Press.

引用

页码：862 / 869

页数：8

共 26 条

[1] Abate V., De Corato R., Cali S., Stinchi A., Endometrial biopsy at the time of embryo transfer: Correlation of histological diagnosis with therapy and pregnancy rate, J. In Vitro Fertil. Embryo Transfer, A, pp. 173-176, (1987)
[2] Asch R., Oocyte donation and gamete intrafallopian transfer as treatment for premature ovarian failure, Lancet, (1987)
[3] Cameron I.T., Rogers P., Salamonsen L.A., Healy D.L., The endocrine requirements for implantation and early embryogenesis in women, J. Reprod. Fertil., 36, pp. 17-25, (1988)
[4] Campbell S., Whitehead M.I., Potency and hepato-cellular effects of oestrogens after oral, percutaneous and subcutaneous administration, The Controversial Climacteric, (1982)
[5] Cohen J.J., Debache C., Pigeau F., Mandelbaum J., Plachot M., De B., Sequential use of clomiphene citrate, human menopausal gonadotropin, and human chorionic gonadotropin in human in vitro fertilization, n. Study of lutal phase adequacy following aspiration of the preovulatory follicles, Fertil. Steril, 42, pp. 360-365, (1984)
[6] Devroey P., Palermo G., Bourgain C., Van Waesberghe L., Smitz J., Van Steirteghem A.C., Progesterone administration in patients with absent ovaries, Int, J. Fertil, 34, pp. 188-193, (1989)
[7] Dusterberg B., Nishino Y., Pharmacokinetic and pharmacological features of oestradiol valerate, Maturitas, 4, (1982)
[8] Edmonds D.K., Lindsay K.S., Miller J.F., Williamson E., Wood P.J., Eariy embryonic mortality in women, Fertil. Steril, 38, (1982)
[9] Freeman L., Trounson A., Kirby C., Cryopreservation of human embryos: Progress on the clinical use of the technique in human in vitro fertilization. J, Vitro Fertil. Embryo Transfer, 3, pp. 53-61, (1986)
[10] Graf M.J., Reyniack J.V., Battle-Mutter P., Laufer N., Histologic evaluation of the luteal phase in women following follicle aspiration for oocyte retrieval, Fertil. Steril, 49, pp. 616-619, (1988)

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