PETITE MUTAGENESIS IN SACCHAROMYCES-CEREVISIAE BY A SERIES OF BIS-CATIONIC TRYPANOCIDAL DRUGS

被引：5

作者：

FERGUSON, LR ^{[1
]}

SUNDBERG, RJ ^{[1
]}

机构：

[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 11期

关键词：

D O I：

10.1128/AAC.35.11.2318

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A group of bis-cationic imidazo[1,2-a]pyridinium salts and related compounds, some of which exhibit in vivo trypanocidal activity, have been investigated for induction of petite mutagenesis in Saccharomyces cerevisiae. All of the compounds which are active trypanocides induce mutagenesis. There appears to be a correlation between trypanocidal activity and mutagenic activity which may have its structural origin in the spatial separation of the cationic centers.

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页码：2318 / 2321

页数：4

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