HUMAN ADENOVIRUS TYPE-5 RECOMBINANTS EXPRESSING SIMIAN IMMUNODEFICIENCY VIRUS MACAQUE STRAIN GAG ANTIGENS

被引：15

作者：

CARAVOKYRI, C ^{[1
]}

PRINGLE, CR ^{[1
]}

LEPPARD, KN ^{[1
]}

机构：

[1] UNIV WARWICK,DEPT BIOL SCI,COVENTRY CV4 7AL,W MIDLANDS,ENGLAND

来源：

JOURNAL OF GENERAL VIROLOGY | 1993年 / 74卷

关键词：

D O I：

10.1099/0022-1317-74-12-2819

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The p55 gag gene of simian immunodeficiency virus macaque strain (SIV(mac)) and the core p27 gag component linked to a synthetic AUG codon have been cloned into adenovirus type 5 vectors to generate either viable E3-replacement or defective E1-replacement viruses. The viruses express the expected SIV proteins in both human and, for the non-defective viruses, monkey cells. A considerable proportion of the p55 produced is exported from the infected cell. These viruses should prove useful both in studies of the immune response to SIV and as components of candidate vaccines aimed specifically at provoking cytotoxic T cell responses.

引用

页码：2819 / 2824

页数：6

共 35 条

[1]

ALMOND N, 1990, J VIROL METHODS, V28, P321

[2] PROTECTION OF CHIMPANZEES FROM INFECTION BY HIV-1 AFTER VACCINATION WITH RECOMBINANT GLYCOPROTEIN GP120 BUT NOT GP160 [J].

BERMAN, PW ;

GREGORY, TJ ;

RIDDLE, L ;

NAKAMURA, GR ;

CHAMPE, MA ;

PORTER, JP ;

WURM, FM ;

HERSHBERG, RD ;

COBB, EK ;

EICHBERG, JW .

NATURE, 1990, 345 (6276) :622-625

[3]

CHANDA PK, 1990, VIROLOGY, V175, P536

[4] COEXPRESSION OF THE SIMIAN IMMUNODEFICIENCY VIRUS ENV AND REV PROTEINS BY A RECOMBINANT HUMAN ADENOVIRUS HOST RANGE MUTANT [J].

CHENG, SM ;

LEE, SG ;

RONCHETTIBLUME, M ;

VIRK, KP ;

MIZUTANI, S ;

EICHBERG, JW ;

DAVIS, A ;

HUNG, PP ;

HIRSCH, VM ;

CHANOCK, RM ;

PURCELL, RH ;

JOHNSON, PR .

JOURNAL OF VIROLOGY, 1992, 66 (11) :6721-6727

[5] TRANSMEMBRANE PROTEIN OF SIV [J].

CRANAGE, MP ;

ALMOND, N ;

JENKINS, A ;

KITCHIN, PA .

NATURE, 1989, 342 (6248) :349-349

[6]

DESROSIERS R C, 1992, Current Biology, V2, P162, DOI 10.1016/0960-9822(92)90278-I

[7] SYNTHESIS AND PROCESSING OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 ENVELOPE PROTEINS ENCODED BY A RECOMBINANT HUMAN ADENOVIRUS [J].

DEWAR, RL ;

NATARAJAN, V ;

VASUDEVACHARI, MB ;

SALZMAN, NP .

JOURNAL OF VIROLOGY, 1989, 63 (01) :129-136

[8]

DEWOLF F, 1988, J INFECT DIS, V158, P615, DOI 10.1093/infdis/158.3.615

[9] IMMUNIZATION BY SELECTIVE INFECTION WITH TYPE 4 ADENOVIRUS GROWN IN HUMAN DIPLOID TISSUE CULTURE .2. SPECIFIC PROTECTIVE EFFECT AGAINST EPIDEMIC DISEASE [J].

EDMONDSON, WP ;

PURCELL, RH ;

GUNDELFINGER, BF ;

LOVE, JWP ;

LUDWIG, W ;

CHANOCK, RM .

JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1966, 195 (06) :453-+

[10] ASSEMBLY AND RELEASE OF HIV-1 PRECURSOR PR55GAG VIRUS-LIKE PARTICLES FROM RECOMBINANT BACULOVIRUS INFECTED INSECT CELLS [J].

GHEYSEN, D ;

JACOBS, E ;

DEFORESTA, F ;

THIRIART, C ;

FRANCOTTE, M ;

THINES, D ;

DEWILDE, M .

CELL, 1989, 59 (01) :103-112

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