THE EFFECT OF MUTATION ON LINKAGE DISEQUILIBRIUM

被引：2

作者：

CAROTHERS, AD

WRIGHT, AF

机构：

[1] Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, Crewe Road

来源：

ANNALS OF HUMAN GENETICS | 1992年 / 56卷

关键词：

D O I：

10.1111/j.1469-1809.1992.tb01141.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The standard formula for the approach to linkage equilibrium between two diallelic loci, initially at disequilibrium, is expressed in terms of their probability of recombination (Li, 1955). By a simple extension, we show how to incorporate the effects of mutation at one or both loci. It can thereby be inferred that in general these effects are unlikely to be of major importance, contrary to some recent suggestions.

引用

页码：155 / 158

页数：4

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