PROGESTERONE SUPPRESSION OF PREGNANCY LYMPHOCYTES IS NOT MEDIATED BY GLUCOCORTICOID EFFECT

被引：32

作者：

SZEKERESBARTHO, J

PHILIBERT, D

CHAOUAT, G

机构：

[1] ROUSSEL UCLAF,ROMAINVILLE,FRANCE

[2] CLIN BAUDELOCQUE,INSERM,U262,PARIS,FRANCE

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1990年 / 23卷 / 02期

关键词：

glucocorticoid receptors; lymphocytes; progesterone;

D O I：

10.1111/j.1600-0897.1990.tb00668.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

ABSTRACT: This study investigated whether the suppressive effect of progesterone on pregnancy lymphocytes is mediated by specific progesterone receptors. The effects of a competitive progesterone antagonist (RU486) and a specific glucocorticoid receptor blocker (RU43044) were tested on the release of a blocking factor by progesterone‐treated pregnancy lymphocytes. RU 486 tested at an equal concentration as progesterone significantly inhibited the production of the blocking factor, while RU 43044 was without effect. These data suggest that in pregnancy, lymphocyte progesterone acts on specific progesterone receptors and glucocorticoid binding sites are not involved. 1990 Munksgaard

引用

页码：42 / 43

页数：2

共 7 条

[1]

LIPPMAN M, 1977, PROGESTERONE RECEPTO, V4, P193

[2]

NEIFELD JP, 1977, J BIOL CHEM, V252, P2972

[3]

Philibert D, 1985, ANTIPROGESTIN STEROI, P49

[4]

SZEKERESBARTHO J, 1985, AM J REPROD IM MIC, V9, P15