PREVALENCE OF INFLAMMATORY BOWEL-DISEASE AMONG RELATIVE OF PATIENTS WITH CROHNS-DISEASE

被引：119

作者：

MONSEN, U ^{[1
]}

BERNELL, O ^{[1
]}

JOHANSSON, C ^{[1
]}

HELLERS, G ^{[1
]}

机构：

[1] HUDDINGE HOSP,DEPT SURG,S-14186 HUDDINGE,SWEDEN

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1991年 / 26卷 / 03期

关键词：

CROHNS DISEASE; FAMILIAL CROHNS DISEASE; INFLAMMATORY BOWEL DISEASE; ULCERATIVE COLITIS;

D O I：

10.3109/00365529109025046

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The prevalence of familial inflammatory bowel disease was 13.4% in a population-based study of 1048 patients with Crohn's disease (CD). Seventy-two of the index cases had 82 first-degree relatives. Forty-nine were more distantly related (19 first cousins from the same generation as the index patient). The prevalence of CD among first-degree relatives was 21 times higher than among non-relatives. Four of six monozygotic twins were concordant. The age at onset was 25 years in the patients with familial CD, compared with 33 years in the entire group. An additional 53 relatives were found to have ulcerative colitis (UC). The prevalence of UC among first-degree relatives of patients with CD was six times higher than among non-relatives.

引用

页码：302 / 306

页数：5

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