ALZHEIMERS-DISEASE AMYLOID PRECURSOR PROTEIN IS PRESENT IN THE MYELIN SHEATH OF CENTRAL-NERVOUS-SYSTEM IN RAT

被引：14

作者：

IKEDA, K ^{[1
]}

TOMONAGA, M ^{[1
]}

机构：

[1] UNIV TOKYO, INST BRAIN RES, DEPT NEUROPATHOL, TOKYO 113, JAPAN

来源：

BRAIN RESEARCH | 1990年 / 527卷 / 01期

关键词：

Alzheimer's disease; Immunohistochemistry; Myelin protein; Myelination; Rat brain; β-Amyloid precursor protein;

D O I：

10.1016/0006-8993(90)91072-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

By using polyclonal antibodies to C- and N-terminal portions of β-amyloid precursor protein (APP), we immunohistochemically examined postnatal and adult rat brains. Immunoreactivity was observed in myelin of nerve fibers in myelination and of mature myelinated fibers, as well as in various brain cells. In trigeminal nerve roots, the immunoreactivity was observed in central myelin but not in peripheral myelin. The results strongly suggest that APP is a component of central myelin in rat. © 1990.

引用

页码：140 / 144

页数：5

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