NEW MODEL FOR 70-KDA HEAT-SHOCK PROTEINS POTENTIAL MECHANISMS OF FUNCTION

被引：28

作者：

TSANG, TC

机构：

[1] Department of Microbiology and Immunology, College of Medicine, University of Arizona, Tucson

来源：

FEBS LETTERS | 1993年 / 323卷 / 1-2期

关键词：

HSP-70; CYTOSKELETON; ACTIN; CROSS-LINKER; TARGETING SEQUENCE; MOLECULAR CHAPERONE;

D O I：

10.1016/0014-5793(93)81435-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 70 kDa family of heat-shock proteins (hsp 70s and hsc 70s) can facilitate protein transport to several organelles. This process is thought to involve electrostatic interactions between hsp 70s and the cellular protein targeting sequences. Analysis of the highly conserved structural and functional properties of the hsp 70 family indicated that they may cross-link cellular proteins to the actin microfilament network. Direct experimental support for this hypothesis was provided by the finding that hsp 70 is constitutively bound to actin through hydrophobic interactions. The cross-linker model may provide an explanation for the mechanism by which the cytoskeletal matrix could mediate various cellular processes.

引用

页码：1 / 3

页数：3

共 32 条

[1] PRINCIPLES THAT GOVERN FOLDING OF PROTEIN CHAINS
ANFINSEN, CB
[J]. SCIENCE, 1973, 181 (4096) : 223 - 230
[2] INTERACTION OF HSP-70 WITH NEWLY SYNTHESIZED PROTEINS - IMPLICATIONS FOR PROTEIN FOLDING AND ASSEMBLY
BECKMANN, RP
MIZZEN, LA
WELCH, WJ
[J]. SCIENCE, 1990, 248 (4957) : 850 - 854
[3] A ROLE FOR A 70-KILODATON HEAT-SHOCK PROTEIN IN LYSOSOMAL DEGRADATION OF INTRACELLULAR PROTEINS
CHIANG, HL
TERLECKY, SR
PLANT, CP
DICE, JF
[J]. SCIENCE, 1989, 246 (4928) : 382 - 385
[4] 70K HEAT-SHOCK RELATED PROTEINS STIMULATE PROTEIN TRANSLOCATION INTO MICROSOMES
CHIRICO, WJ
WATERS, MG
BLOBEL, G
[J]. NATURE, 1988, 332 (6167) : 805 - 810
[5] IS HSP70 THE CELLULAR THERMOMETER
CRAIG, EA
GROSS, CA
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1991, 16 (04) : 135 - 140
[6] A SUBFAMILY OF STRESS PROTEINS FACILITATES TRANSLOCATION OF SECRETORY AND MITOCHONDRIAL PRECURSOR POLYPEPTIDES
DESHAIES, RJ
KOCH, BD
WERNERWASHBURNE, M
CRAIG, EA
SCHEKMAN, R
[J]. NATURE, 1988, 332 (6167) : 800 - 805
[7] THE NUCLEAR-MEMBRANE
DINGWALL, C
LASKEY, R
[J]. SCIENCE, 1992, 258 (5084) : 942 - 947
[8] EDDY RJ, 1992, 32ND ASCB ANN M, pA40
[9] PROTEINS AS MOLECULAR CHAPERONES
ELLIS, J
[J]. NATURE, 1987, 328 (6129) : 378 - 379
[10] SIMILARITY OF THE 3-DIMENSIONAL STRUCTURES OF ACTIN AND THE ATPASE FRAGMENT OF A 70-KDA HEAT-SHOCK COGNATE PROTEIN
FLAHERTY, KM
MCKAY, DB
KABSCH, W
HOLMES, KC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (11) : 5041 - 5045

← 1 2 3 4 →