Molecular diversity of GABA-gated chloride channels in the rat anterior pituitary

被引：20

作者：

BoueGrabot, E ^{[1
]}

Dufy, B ^{[1
]}

Garret, M ^{[1
]}

机构：

[1] UNIV BORDEAUX 2,CNRS URA 1200,NEUROPHYSIOL LAB,F-33076 BORDEAUX,FRANCE

来源：

BRAIN RESEARCH | 1995年 / 704卷 / 01期

关键词：

GABA(A)receptor; GABA(C) receptor; reverse-transcribed polymerase chain reaction; pituitary;

D O I：

10.1016/0006-8993(95)01192-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

mRNA expression of GABA-gated Cl--channels in rat antepituitary was evaluated by using an reverse-transcribed (RT)-polymerase chain reaction (RT-PCR) method with degenerate and specific oligonucleotides. The main result of our findings is that the antepituitary expresses mRNAs encoding alpha 4 and rho 1 GABA receptor subunits. These two subunits are believed to be, respectively, constituents of benzodiazepine-insensitive GABA(A) and GABA(C) receptors in the CNS. This molecular analysis is consistent with the pharmacological diversity of GABA receptors in pituitary cells.

引用

页码：125 / 129

页数：5

共 30 条

[1]

GAMMA-AMINOBUTYRIC-ACID STIMULATES PITUITARY GROWTH-HORMONE SECRETION IN THE NEONATAL RAT - A SUPERFUSION STUDY [J].

ACS, Z ;

SZABO, B ;

KAPOCS, G ;

MAKARA, GB .

ENDOCRINOLOGY, 1987, 120 (05) :1790-1798

[2]

BIPHASIC EFFECT OF GABA-A RECEPTOR AGONISTS ON PROLACTIN SECRETION - EVIDENCE FOR 2 TYPES OF GABA-A RECEPTOR COMPLEX ON LACTOTROPHES [J].

ANDERSON, R ;

MITCHELL, R .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 124 (1-2) :1-9

[3]

BERMAN JA, 1994, J NEUROCHEM, V63, P1948

[4]

TRANSCRIPTION OF THE DYSTROPHIN GENE IN HUMAN-MUSCLE AND NON-MUSCLE TISSUES [J].

CHELLY, J ;

KAPLAN, JC ;

MAIRE, P ;

GAUTRON, S ;

KAHN, A .

NATURE, 1988, 333 (6176) :858-860

[5]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[6]

IDENTIFICATION OF A PUTATIVE GAMMA-AMINOBUTYRIC-ACID (GABA) RECEPTOR SUBUNIT RHO(2) CDNA AND COLOCALIZATION OF THE GENES ENCODING RHO(2) (GABRR2) AND RHO(1) (GABRR1) TO HUMAN-CHROMOSOME 6Q14-Q21 AND MOUSE CHROMOSOME-4 [J].

CUTTING, GR ;

CURRISTIN, S ;

ZOGHBI, H ;

OHARA, B ;

SELDIN, MF ;

UHL, GR .

GENOMICS, 1992, 12 (04) :801-806

[7]

CLONING OF THE GAMMA-AMINOBUTYRIC-ACID (GABA) RHO-1 CDNA - A GABA RECEPTOR SUBUNIT HIGHLY EXPRESSED IN THE RETINA [J].

CUTTING, GR ;

LU, L ;

OHARA, BF ;

KASCH, LM ;

MONTROSERAFIZADEH, C ;

DONOVAN, DM ;

SHIMADA, S ;

ANTONARAKIS, SE ;

GUGGINO, WB ;

UHL, GR ;

KAZAZIAN, HH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (07) :2673-2677

[8]

ANALYSIS OF GENE-EXPRESSION IN SINGLE LIVE NEURONS [J].

EBERWINE, J ;

YEH, H ;

MIYASHIRO, K ;

CAO, YX ;

NAIR, S ;

FINNELL, R ;

ZETTEL, M ;

COLEMAN, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :3010-3014

[9]

RECENT ADVANCES IN THE POLYMERASE CHAIN-REACTION [J].

ERLICH, HA ;

GELFAND, D ;

SNINSKY, JJ .

SCIENCE, 1991, 252 (5013) :1643-1651

[10]

LOCALIZATION OF GABA-A RECEPTORS IN THE RAT RETINA [J].

GREFERATH, U ;

MULLER, F ;

WASSLE, H ;

SHIVERS, B ;

SEEBURG, P .

VISUAL NEUROSCIENCE, 1993, 10 (03) :551-561

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