DYSTROPHIN AND UTROPHIN - THE MISSING LINKS

被引:124
作者
WINDER, SJ [1 ]
GIBSON, TJ [1 ]
KENDRICKJONES, J [1 ]
机构
[1] EUROPEAN MOLEC BIOL LAB,D-69012 HEIDELBERG,GERMANY
关键词
UTROPHIN; DYSTROPHIN; SPECTRIN; ACTIN BINDING; COILED-COIL;
D O I
10.1016/0014-5793(95)00398-S
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
There is considerable sequence homology between dystrophin and utrophin, both at the protein and DNA level, and consequently it was assumed that their domain structures and functions would be similar, As more of the detailed biochemical and cell biological properties of these two proteins become known, so it becomes clear that there are subtle if not significant differences between them, We review recent findings and present new hypotheses into the structural and functional properties of the actin-binding domain, central coiled-coil region and regulatory/membrane protein-binding regions of dystrophin and utrophin.
引用
收藏
页码:27 / 33
页数:7
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