1-METHYL-4-PHENYLPYRIDINIUM ION (MPP+) - IDENTIFICATION OF A METABOLITE OF MPTP, A TOXIN SELECTIVE TO THE SUBSTANTIA NIGRA

被引：409

作者：

LANGSTON, JW

IRWIN, I

LANGSTON, EB

FORNO, LS

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,STANFORD,CA 94305

[2] VET ADM MED CTR,DEPT PATHOL,PALO ALTO,CA 94304

来源：

NEUROSCIENCE LETTERS | 1984年 / 48卷 / 01期

关键词：

D O I：

10.1016/0304-3940(84)90293-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

引用

页码：87 / 92

页数：6

共 10 条

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SCIENCE, 1981, 214 (4527) :1370-1372

[3] A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].

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[4] ETIOLOGY OF PARKINSONS-DISEASE [J].

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[5]

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[6]

HOAG MKP, DRUG METAB DISPOS

[7] CHRONIC PARKINSONISM IN HUMANS DUE TO A PRODUCT OF MEPERIDINE-ANALOG SYNTHESIS [J].

LANGSTON, JW ;

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IRWIN, I .

SCIENCE, 1983, 219 (4587) :979-980

[8]

LANGSTON JW, 1984, BRAIN RES, V292, P390

[9]

LYLE RE, 1962, TETRAHEDRON LETT, V13, P553

[10]

RODIG OR, 1974, PYRIDINE ITS DER 1 S, V14, P309

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