F-19 NMR NON-EQUIVALENCE OF DIASTEREOMERIC AMIDES OF 2,2,2-TRIFLUORO-1-PHENYLETHYLAMINE

被引：36

作者：

WANG, Y ^{[1
]}

MOSHER, HS ^{[1
]}

机构：

[1] STANFORD UNIV,DEPT CHEM,STANFORD,CA 94305

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(00)74468-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An alternate synthesis and resolution is reported for 2,2,2-trifluoro-1-phenylethylamine. The F-19 NMR of a series of amide derivatives of chiral acids is described. The diastereomeric non-equivalence of the F-19 NMR signals (0.05-0.09 ppm) of these amides permits use of these derivatives for determination of enantiomeric purity of alpha--substituted acids. The potential for configurational correlations is discussed.

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页码：987 / 990

页数：4

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