HIGH-RISK OF CELIAC-DISEASE IN PUNJABIS - EPIDEMIOLOGIC-STUDY IN THE SOUTH ASIAN AND EUROPEAN POPULATIONS OF LEICESTERSHIRE

被引:49
作者
SHER, KS [1 ]
FRASER, RC [1 ]
WICKS, AC [1 ]
MAYBERRY, JF [1 ]
机构
[1] UNIV LEICESTER,DEPT GEN PRACTICE,LEICESTER LE1 7RH,ENGLAND
关键词
CELIAC DISEASE; PUNJABIS; EUROPEANS;
D O I
10.1159/000201035
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The purpose of this study was to measure the incidence of coeliac disease in different ethnic communities and investigate the hypothesis that the incidence is decreasing in most European countries and the role incomplete retrieval of data may play. In a retrospective study of histologically confirmed cases of coeliac disease between 1975 and 1989 in the City of Leicester, 106 patients with coeliac disease were identified. Of these 86 were European and 20 Asian. The overall incidence of coeliac disease in Europeans was 2.5/10(5)/year (95% CI 2-3.2), in Gujaratis 0.9/10(5)/year (95% CI 0.4-1.8), and in Punjabis 6.9 (95% CI 3.2-12.3). These differences were independent of religious belief. The relative risk to Punjabis compared with Europeans is 2.9 (95% CI 1.5-5.3; chi2 = 12.5, p < 0.01) and to Gujaratis 8.1 (95% CI 3-22.4; chi2 = 25; p < 0.001). Gujaratis were at 0.4 risk of Europeans (90% CI 0.2-0.8; chi2 = 6.7; p < 0.01). The incidence in the urban populations of Leicester was 6/10(5)/year (95% CI 1.3-1.9) which was significantly lower than the 3.2/10(5)/year (95% CI 2.7-3.8; chi2 = 5.6; p < 0.001) in surrounding rural areas. This study shows that the incidence of coeliac disease in Punjabis (Sikhs, Hindus and Muslims) is 8 times higher than in Gujaratis (Hindus and Muslims) and 4 times higher than in Europeans in Leicester.
引用
收藏
页码:178 / 182
页数:5
相关论文
共 29 条
[1]  
Acalovschi M, 1992, Qual Health Care, V1, P26, DOI 10.1136/qshc.1.1.26
[2]   INCIDENCE OF CELIAC-DISEASE AND TRANSIENT GLUTEN INTOLERANCE IN CHILDREN IN A SWEDISH URBAN-COMMUNITY [J].
BERG, NO ;
LINDBERG, T .
ACTA PAEDIATRICA SCANDINAVICA, 1979, 68 (03) :397-400
[3]  
BRUETON MJ, 1981, GENETICS COELIAC DIS, P103
[4]  
CARRINGTON JM, 1987, NZ MED J, V100, P480
[5]   INCREASING INCIDENCE OF CHILDHOOD CELIAC-DISEASE IN SWEDEN - RESULTS OF A NATIONAL STUDY [J].
CAVELL, B ;
STENHAMMAR, L ;
ASCHER, H ;
DANIELSSON, L ;
DANNAEUS, A ;
LINDBERG, T ;
LINDQUIST, B .
ACTA PAEDIATRICA, 1992, 81 (08) :589-592
[6]  
CLUYSENAER OJJ, 1977, MALBSORPTION COELIAC
[7]  
DAHAN H, 1984, J EPID COMM HLTH, V38, P58
[8]   IS GLUTEN CHALLENGE NECESSARY FOR THE DIAGNOSIS OF CELIAC-DISEASE IN YOUNG-CHILDREN [J].
DANIELSSON, L ;
STENHAMMAR, L ;
ASTROM, E .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1990, 25 (09) :957-960
[9]   UNCHANGING CLINICAL PICTURE OF CELIAC-DISEASE PRESENTATION IN CAMPANIA, ITALY [J].
GRECO, L ;
TOZZI, AE ;
MAYER, M ;
GRIMALDI, M ;
SILANO, G ;
AURICCHIO, S .
EUROPEAN JOURNAL OF PEDIATRICS, 1989, 148 (07) :610-613
[10]  
KOKKONEN J, 1982, ANN CLIN RES, V14, P123