FORMULATION, INVITRO RELEASE AND THERAPEUTIC EFFECT OF HYDROGELS BASED CONTROLLED RELEASE TABLETS OF PROPRANOLOL HYDROCHLORIDE

被引：11

作者：

GANGA, S ^{[1
]}

SINGH, PN ^{[1
]}

SINGH, J ^{[1
]}

机构：

[1] BANARAS HINDU UNIV,INST TECHNOL,DEPT PHARMACEUT,VARANASI 221005,UTTAR PRADESH,INDIA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1992年 / 18卷 / 19期

关键词：

D O I：

10.3109/03639049209040919

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Matrix based controlled release tablets of Propranolol Hydrochloride (PHCL) were formulated using hydroxy propyl methyl cellulose (HPMC), sodium carboxy methyl cellulose (sod. CMC) and their combinations. The in-vitro dissolution kinetics revealed a zero order release for selected drug, HPMC and sod. CMC combination. The selected formulation was evaluated in mongrel dog by recording the isoprenaline induced tachycardia and measuring the inhibition of tachycardia. The results showed the sustaining therapeutic effect of the formulation.

引用

页码：2049 / 2066

页数：18

共 15 条

[1]

ZERO-ORDER RELEASE HYDROPHILIC MATRIX TABLETS OF BETA-ADRENERGIC BLOCKERS [J].

BAVEJA, SK ;

RAO, KVR ;

DEVI, KP .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 39 (1-2) :39-45

[2]

SUSTAINED-RELEASE TABLET FORMULATION OF CENTPERAZINE [J].

BAVEJA, SK ;

RAO, KVR .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 31 (1-2) :169-174

[3]

GANDER B, 1986, PHARM ACTA HELV, V61, P178

[4]

GANDER B, 1986, PHARM ACTA HELV, V61, P130

[5]

MECHANISM OF SUSTAINED-ACTION MEDICATION - THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES [J].

HIGUCHI, T .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1963, 52 (12) :1145-&

[6]

DRUG RELEASE FROM COMPRESSED HYDROPHILIC MATRICES [J].

LAPIDUS, H ;

LORDI, NG .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1968, 57 (08) :1292-&

[7]

LORDI GN, 1987, THEORY PRACTICE IND, P453

[8]

MAXWELL DR, 1972, MED TODAY, V6, P85

[9]

CELLULOSE MATRICES FOR ZERO-ORDER RELEASE OF SOLUBLE DRUGS [J].

RAO, KVR ;

DEVI, KP ;

BURI, P .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1988, 14 (15-17) :2299-2320

[10]

GEL MATRIX SYSTEMS EXHIBITING BIMODAL CONTROLLED RELEASE FOR ORAL-DRUG DELIVERY [J].

SHAH, AC ;

BRITTEN, NJ ;

OLANOFF, LS ;

BADALAMENTI, JN .

JOURNAL OF CONTROLLED RELEASE, 1989, 9 (02) :169-175

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