HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY (HPLC) CHIRAL SEPARATIONS OF GUAIFENESIN, METHOCARBAMOL, AND RACEMORPHAN

被引：13

作者：

DEMIAN, I

机构：

[1] Boehringer Ingelheim Chemicals, Inc., Petersburg, Virginia

来源：

CHIRALITY | 1993年 / 5卷 / 04期

关键词：

CHIRAL HPLC; CHIRALCEL OD; CHIRALCEL OD-R; GUAIFENESIN; METHOCARBAMOL; DEXTROMETHORPHAN; LEVOMETHORPHAN; RACEMORPHAN;

D O I：

10.1002/chir.530050409

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

HPLC chiral separations on silica gel coated with derivatized cellulose stationary phases are described. Most examples make use of the Chiralcel OD column from Daicel, Inc. With a judiciously chosen mobile phase, baseline separations of the enantiomers can be achieved. If those separations are used as a base for enantiomeric purity determination, detectable limits of 0.1% of the minor enantiomer are routinely accessible. Examples are given concerning separations of guaifenesin, methocarbamol, and racemorphan. (C) 1993 Wiley-Liss, Inc.

引用

页码：238 / 240

页数：3