TOWARDS THE CHEMOENZYMATIC SYNTHESIS OF LIPID-A

被引:30
作者
SUGAI, T [1 ]
RITZEN, H [1 ]
WONG, CH [1 ]
机构
[1] Scripps Res Inst, DEPT CHEM, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA
关键词
D O I
10.1016/S0957-4166(00)80153-6
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
New procedures have been developed for the synthesis of the two impotant components of lipid A; one is the lipase-catalyzed resolution of 3-hydrxytetradecanoic acid in tetrahydrofuran using vinyl acetate and the other is the synthesis of the disaccharide moiety using glycosylphosphite as the glycosylating reagent.
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页码:1051 / 1058
页数:8
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