GAS-CHROMATOGRAPHIC ENANTIOMER SEPARATION OF PHARMACEUTICALS ON CAPILLARY COLUMNS COATED WITH NOVEL CHIRAL POLYSILOXANES

被引：5

作者：

ABE, I ^{[1
]}

NISHIYAMA, T ^{[1
]}

NAKAHARA, T ^{[1
]}

FRANK, H ^{[1
]}

机构：

[1] UNIV TUBINGEN,INST TOXICOL,D-72074 TUBINGEN,GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY A | 1995年 / 694卷 / 01期

关键词：

D O I：

10.1016/0021-9673(94)00835-W

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Six chiral polysiloxanes were prepared by block condensation of 3-(dichloromethylsilyl)-2-methylpropionic acid 2',2',2'-trifluoroethyl ester with disodium tetramethyldisiloxane1-,3-diolate and subsequent nucleophilic displacement with chiral amines. The polysiloxanes were coated on to capillaries and the capillary columns were used for the gas chromatographic separation of pharmaceutical enantiomers. The columns showed sufficient enantioselectivity and thermal stability to separate various pharmaceuticals into enantiomeric pairs within a reasonable time. (S)-Valine-(R)-1-(alpha-naphthylethyl)amide polysiloxane showed better enantioselectivity, and (S)-valine-(d)-menthylamide-modified polysiloxane gave a higher coating efficiency than the other phases.

引用

页码：237 / 243

页数：7

共 19 条

[1]

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[2]

BEITLER U, 1976, J CHROMATOGR, V12, P149

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