THE ULTIMATE CARCINOGEN, O-ACETYL-N-(2-FLUORENYL)HYDROXYLAMINE (N-ACETOXY-2-AMINOFLUORENE), AND ITS REACTION INVITRO TO FORM 2-[N-(DEOXYGUANOSIN-8-YL)AMINO]FLUORENE

被引：29

作者：

BOSOLD, F ^{[1
]}

BOCHE, G ^{[1
]}

机构：

[1] UNIV MARBURG,FACHBEREICH CHEM,HANS MEERWEIN STR,W-3550 MARBURG,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1990年 / 29卷 / 01期

关键词：

D O I：

10.1002/anie.199000631

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The extremely unstable carcinogen 1 has now been synthesized. It was allowed to react with deoxyguanosine to give the adduct 2, the only non‐acylated adduct which could also be isolated from the DNA of animals previously treated with 2‐acetylaminofluorene and 2‐aminofluorene. According to in vivo and in vitro investigations 1 must be regarded as the ultimate carcinogen of the said carcinogenic aromatic amines. (Figure Presented.) Copyright © 1990 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：63 / 64

页数：2

共 26 条

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