METRONIDAZOLE AND DRUG-RESISTANCE

被引：107

作者：

JOHNSON, PJ

机构：

[1] Patricia J. Johnson is at the Department of Microbiology and Immunology, University of California, Los Angeles

来源：

PARASITOLOGY TODAY | 1993年 / 9卷 / 05期

关键词：

D O I：

10.1016/0169-4758(93)90143-4

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

In recent years, the basis of metronidazole resistance has been examined in anaerobic protozoa, such as Trichomonas and Giardia, as well as anaerobic bacteria, such as Bacteroides and Clostridium. In this review, Patricia Johnson looks at a variety of mechanisms that lead to reduced susceptibility of these pathogens to the drug The frequent correlation between metronidazole resistance and inefficient drug activation suggests that this is the level at which drug resistance operates.

引用

页码：183 / 186

页数：4

共 50 条

[1] LACK OF EVIDENCE FOR CANCER DUE TO USE OF METRONIDAZOLE [J].

BEARD, CM ;

NOLLER, KL ;

OFALLON, WM ;

KURLAND, LT ;

DOCKERTY, MB .

NEW ENGLAND JOURNAL OF MEDICINE, 1979, 301 (10) :519-522

[2] DEMONSTRATION OF RADIOSENSITIZATION OF HYPOXIC CELLS IN SOLID TUMORS BY METRONIDAZOLE [J].

BEGG, AC ;

SHELDON, PW ;

FOSTER, JL .

BRITISH JOURNAL OF RADIOLOGY, 1974, 47 (559) :399-404

[3] TRANSFERABLE 5-NITROIMIDAZOLE RESISTANCE IN THE BACTEROIDES-FRAGILIS GROUP [J].

BREUIL, J ;

DUBLANCHET, A ;

TRUFFAUT, N ;

SEBALD, M .

PLASMID, 1989, 21 (02) :151-154

[4] ISOLATION AND PROPERTIES OF METRONIDAZOLE-RESISTANT MUTANTS OF BACTEROIDES-FRAGILIS [J].

BRITZ, ML ;

WILKINSON, RG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 16 (01) :19-27

[5]

CALLAHAN HL, 1991, J BIOL CHEM, V266, P18427

[6]

CERKASOVOVA A, 1986, Acta Universitatis Carolinae-Biologica, V30, P485

[7]

CERKASOVOVA A, 1988, ACTA U CAROL BIOL, V30, P505

[8] METABOLIC DIFFERENCES BETWEEN METRONIDAZOLE RESISTANT AND SUSCEPTIBLE STRAINS OF TRITRICHOMONAS-FOETUS [J].

CERKASOVOVA, AP ;

CERKASOV, J ;

KULDA, J .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1984, 11 (APR) :105-118

[9] REDUCTION OF 2-NITROIMIDAZOLE, 4-NITROIMIDAZOLE AND 5-NITROIMIDAZOLE DRUGS BY HYDROGENASE-1 IN CLOSTRIDIUM-PASTEURIANUM [J].

CHURCH, DL ;

RABIN, HR ;

LAISHLEY, EJ .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 25 (01) :15-23

[10] ROLE OF HYDROGENASE-1 OF CLOSTRIDIUM-PASTEURIANUM IN THE REDUCTION OF METRONIDAZOLE [J].

CHURCH, DL ;

RABIN, HR ;

LAISHLEY, EJ .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (08) :1525-1534

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