MUSK XYLENE IS A NOVEL SPECIFIC INDUCER OF CYTOCHROME P-450IA2

被引：26

作者：

IWATA, N

MINEGISHI, K

SUZUKI, K

OHNO, Y

KAWANISHI, T

TAKAHASHI, A

机构：

[1] NATL INST HYG SCI,DIV PATHOL,TOKYO 158,JAPAN

[2] NATL INST HYG SCI,DIV PHARMACOL,TOKYO 158,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)91171-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of musk xylene on contents of both cytochrome P-450IA1 and cytochrome P-450IA2 in rat liver was investigated using Western blotting analysis. Rats were treated i.p. for five consecutive days with either 50, 100 or 200 mg musk xylene/kg body weight. Musk xylene increased both total cytochrome P-450 and cytochrome b5 contents in rat liver microsomes. Musk xylene induced cytochrome P-450IA2 (384 pmol/mg protein) strongly and preferentially and the ratio of cytochrome P450IA2 P-450IA1 was about 12 at the lowest dose tested. Musk xylene also induced the cytochrome P-450IA1 dose-dependently, but these extents were very small (32-174 pmol/mg protein). These results suggest that musk xylene may be a more specific inducer for cytochrome P-450IA2 than any other inducers reported. © 1992.

引用

页码：149 / 153

页数：5

共 18 条

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